铜死亡概念:
铜死亡一种新的细胞死亡方式,是由于线粒体中铜的积累,靶向脂酰化 TCA循环蛋白诱导细胞死亡。

上图来源:Tsvetkov, Peter, et al. "Copper induces cell death by targeting lipoylated TCA cycle proteins." Science 375.6586 (2022): 1254-1261.
基因分类
pro-cuproptosis genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, and PDHB);
anti-cuproptosis genes(MTF1, GLS, and CDKN2A);
copper transporters ATP7B and SLC31A1.
产品内容